Study on children with eosmophilic esophagisitis.

2198674880

Thirty-five children, aged 7 months to 12 years, with EoE were enrolled in the study. They had a clinical history of GERD-like (21 children, Group A), or more severe symptoms (14 children, Group B). The diagnosis had been confirmed after two preliminary months of therapy with PPIs and an esophagogastroduodenoscopy. Soon after diagnosis they were allergy-tested, using IgE-detection (SPT and serum specific IgE) and Atopy-Patch-Tests (APT). A 12-month tailor-made diet was prescribed according to the tests. Patients of Group B cotinued PPIs for two more months, while swallowed topical steroids were also prescribed to them for the first 5 months after diagnosis, followed by an ‘as-needed’ use of them for the rest of the study. Endoscopy was repeated at the end of the study.

Results

Milk and egg were the most common APT-positive allergens. 32 patients were instructed to follow an elimination diet, which was completed by 15/18 of Group A and 12/14 of Group B. An improvement of symptoms was reported by 26/27 patients that completed the study. The use of swallowed corticosteroids was noticeably decreased during the as-needed period, in Group B. A remarkable reduce of eosinophils was noticed in biopsies; from 42.84±18.08 they decreased to 6.41±3.20, a year after.

Conclusion

All children with EoE and mild symptoms had resolution of symptoms and normal eosinophils in the esophageal mucosa a year after an allergy-driven elimination diet. Patients with moderate/severe EoE-symptoms had the same improvement, indicating that an elimination diet is an efficient complementary treatment to corticosteroids.

by ICOEF